Optimization of pathogenetic therapy of patients with tick-borne rickettsiosis caused by rickettsiae heilongjiangensis in Khabarovsk Territory

DOI: https://doi.org/10.29296/25877305-2024-03-10
Issue: 
3
Year: 
2024

Associate Professor E. Mokretsova(1), Candidate of Medical Sciences; Professor
G. Tomilka(1), MD; Professor Yu. Kovalskiy(1), MD; Associate Professor A. Schupak(1), Candidate of Medical Sciences; N. Golubkina(3), Doctor of Agricultural Sciences; Professor V. Maleev(2), Academician of the Russian Academy of Sciences, MD
1-Far Eastern State Medical University, Khabarovsk
2-Central Research Institute of Epidemiology of Rospotrebnadzor, Moscow
3-Federal Research Center for Vegetable Growing, Moscow

Objective. To study the dynamics of selenium level and some indexes of oxidative status of blood serum in patients with the moderate form of tick-borne rickettsiosis caused by Rickettsiaе heilongjiangensis, in Khabarovsk Region, depending on the treatment in order to optimize the pathogenetic therapy. Materials and methods. Comparative analysis of combinations of treatment by basic means (antibiotics, detoxication therapy) and in combination with organic selenium was carried out on the basis of determination of nutrient selenium level and some parameters of oxidative status in blood serum of patients with tick-borne rickettsiosis determined by R. heilongjiangensis without accompanying chronic diseases at decompensation stage. Results. The daily dosage of «paprika» powder at a dose of 60 mcg/day allowed to level the selenium deficiency to a suboptimal level of supply. Besides, analysis of chemiluminescence of blood sera of patients who received organic selenium as a part of complex treatment showed activation of antioxidant antiradical protection and decrease of free radicals production against the background of improvement of clinical status. Conclusions. Thus, the complementary therapy with organic selenium promotes normalization of antioxidant protection processes and reliably restores suboptimal provision of selenium and can be recommended for treatment of tick-borne rickettsiosis patients caused by R. heilongjiangensis.
Keywords: 
tick-borne rickettsiosis
Rickettsiae heilongjiangensis
selenium
oxidative stress.

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