TREATMENT OF PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICEAL BLEEDING

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Issue: 
10
Year: 
2015

Professor D. Garbuzenko, MD South Ural State Medical University, Chelyabinsk

Overall measures in the management of these patients to maintain vital functions are combined with specific treatment (pharmacotherapy with vasoactive agents + endoscopic hemostatic methods); if inefficient, it is best to perform transjugular intrahepatic portosystemic shunt.
Keywords: 
liver cirrhosis
portal hypertension
esophageal variceal bleeding
treatment

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References: 
  1. Rajoriya N., Tripathi D. Historical overview and review of current day treatment in the management of acute variceal haemorrhage // World J. Gastroenterol. – 2014; 20 (21): 6481–94
  2. .Hsu Y., Chung C., Tseng C. et al. Delayed endoscopy as a risk factor for . in-hospital mortality in cirrhotic patients with acute variceal hemorrhage // J. Gastroenterol. Hepatol. – 2009; 24 (7): 1294–9.
  3. Carbonell N., Pauwels A., Serfaty L. et al. Improved survival after variceal . bleeding in patients with cirrhosis over the past two decades // Hepatology. – 2004; 40 (3): 652–9.
  4. Amitrano L., Guardascione M., Manguso F. et al. The effectiveness of current acute variceal bleed treatments in unselected cirrhotic patients: refining short-term prognosis and risk factors // Am. J. Gastroenterol. – 2012; 107 (12): 1872–8.
  5. Reverter E., Tandon P., Augustin S. et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding // Gastroenterology. – 2014; 146 (2): 412–9.
  6. Villanueva C., Colomo A., Bosch A. et al. Transfusion Strategies for Acute Upper Gastrointestinal Bleeding // N. Engl. J. Med. – 2013; 368 (1): 11–21.
  7. Lisman T., Porte R. Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences // Blood. – 2010; 116 (6): 878–85.
  8. Arshad F., Stoof S., Leebeek F. et al. Infusion of DDAVP does not improve primary hemostasis in patients with cirrhosis // Liver Int. – 2015; 35 (7): 1809–15
  9. Bendtsen F., D'Amico G., Rusch E. et al. Effect of recombinant Factor VIIa on outcome of acute variceal bleeding: an individual patient based meta-analysis of two controlled trials // J. Hepatol. – 2014; 61 (2): 252–9.
  10. Garbuzenko D.V., Mikurov A.A. Rol' endotoksemii v razvitii krovote chenij iz varikozno-rasshirennyh ven pischevoda u bol'nyh tsirrozom pecheni // Ros. med. zhurn. – 2011; 6: 47–9.
  11. Chavez-Tapia N., Barrientos-Gutierrez T., Tellez-Avila F. et al. Meta-11. analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding - an updated Cochrane review // Aliment. Pharmacol. Ther. – 2011; 34 (5): 509–18.
  12. Lata J. Hepatorenal syndrome // World J. Gastroenterol. – 2012; 18 (36): 4978–84.
  13. De Franchis R. Baveno V Faculty. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension // J. Hepatol. – 2015; 63 (3): 743–52.
  14. Garbuzenko D.V. Contemporary concepts of the medical therapy of portal hypertension under liver cirrhosis // World J. Gastroenterol. – 2015; 21 (20): 6117–26.
  15. Wells M., Chande N., Adams P. et al. Meta-analysis: vasoactive medications for the management of acute variceal bleeds // Aliment. Pharmacol. Ther. – 2012; 35 (11): 1267–78.
  16. Møller S., Hansen E., Becker U. et al. Central and systemic haemodynamic effects of terlipressin in portal hypertensive patients // Liver. – 2000; 20 (1): 51–9.
  17. Ioannou G., Doust J., Rockey D. Systematic review: terlipressin in acute oesophageal variceal haemorrhage // Aliment. Pharmacol. Ther. – 2003; 17 (1): 53–64.
  18. Escorsell A., Bandi J., Andreu V. et al. Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension // Gastroenterology. – 2001; 120 (1): 161–9.
  19. Abraldes J., Bosch J. Somatostatin and analogues in portal hypertension // Hepatology. – 2002; 35 (6): 1305–12.
  20. Laine L., Planas R., Nevens F. et al. Treatment of the acute bleeding episode. In: de Franchis R, editor. Portal Hipertension IV. Proceedings of the fourth Baveno International Consensus Workshop on methodology of diagnosis and treatment / Oxford: Blackwell Publishing, 2006; p. 217–42.
  21. D'Amico G., Pietrosi G., Tarantino I. et al. Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis // Gastroenterology. – 2003; 124 (5): 1277–91.
  22. Baares R., Albillos A., Rincón D. et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis // Hepatology. – 2002; 35 (3): 609–15.
  23. Lo G., Chen W., Wang H. et al. Low-dose terlipressin plus banding ligation versus low-dose terlipressin alone in the prevention of very early rebleeding of oesophageal varices // Gut. – 2009; 58 (9): 1275–80.
  24. Liu J., Liu J. Comparison of emergency endoscopic variceal ligation plus 24. octreotide or octreotide alone for acute esophageal variceal bleeding // Chin. Med. J. – 2009; 122 (24): 3003–6.
  25. Cárdenas A., Fernández-Simon A., Escorcell A. Endoscopic band ligation and Esophageal stents for acute variceal bleeding // Clin. Liver Dis. – 2014; 18 (4): 793–808.
  26. Loffroy R., Estivalet L., Cherblanc V. et al. Transjugular intrahepatic 26. portosystemic shunt for the management of acute variceal hemorrhage // World J. Gastroenterol. – 2013; 19 (37): 6131–43.
  27. Garcia-Pag27. án J., Di Pascoli M., Caca K. et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study // J. Hepatol. – 2013; 58 (1): 45–50.
  28. Orloff M. Fifty-three years' experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in Cirrhosis: 1958–2011 // JAMA Surg. – 2014; 149 (2): 155–69.
  29. Voros D., Polydorou A., Polymeneas G. et al. Long-term results with the modified Sugiura procedure for the management of variceal bleeding: standing the test of time in the treatment of bleeding esophageal varices // World J. Surg. – 2012; 36 (3): 659–66.
  30. Shertsinger A.G., Manuk'jan G.V., Zhigalova S.B. i dr. Modifikatsija operatsii M.D. Patsiory u bol'nyh portal'noj gipertenziej // Hirurgija. – 2012; 10: 9–13.