Кальцификация сосудов и почек как следствие приема высокодозированных препаратов кальция и витамина D

DOI: https://doi.org/10.29296/25877305-2024-02-15
Номер журнала: 
2
Год издания: 
2024

В.И. Струков(1), доктор медицинских наук, профессор,
М.Ю. Сергеева-Кондраченко(1), доктор медицинских наук, профессор,
А.Г. Денисова(1), доктор медицинских наук,
И.Я. Моисеева2, доктор медицинских наук, профессор,
О.П. Виноградова(1), доктор медицинских наук, профессор,
Е.С. Панина(2), кандидат медицинских наук,
Е.В. Петрова(2), кандидат медицинских наук, доцент,
Н.Г. Галкина(2), кандидат медицинских наук, доцент,
А.А. Пронькина(2), О.С. Горина(3), Д.Г. Елистратов(4),
С.С. Бурмистрова(5), Д.Д. Агафонов(2)
1-Пензенский институт усовершенствования врачей –
филиал Российской медицинской академии непрерывного
профессионального образования Минздрава России
2-Пензенский государственный университет
3-Пензенская областная клиническая больница им. Н.Н. Бурденко
4-Медицинский центр «Академия здоровья», Пенза
5-Рязанский государственный медицинский университет
им. акад. И.П. Павлова
E-mail: villor3737@yandex.ru

В перечне антиостеопоротических средств важное место отводится кальцийсодержащим препаратам. Их потребление, зачастую в комплексе с высокими дозами витамина D, за последние пару десятилетий значительно возросло. Участились случаи бесконтрольного приема макроэлемента. Свою роль в этом сыграла и агрессивная реклама высокодозированных добавок кальция с кальциферолом зарубежного производства по телевидению. В наши дни врачам разных специальностей все чаще приходится сталкиваться с последствиями применения подобных препаратов. В статье описан механизм образования кальциевых отложений в сосудах и почках на фоне приема добавок кальция. Приведены результаты крупномасштабных исследований, доказывающих тесную взаимосвязь между высоким потреблением кальция и витамина D с кальцификацией сосудов, развитием сердечно-сосудистых заболеваний и нефролитиазом. Высказываются сомнения по поводу обоснованности и необходимости применения высокодозированных кальциевых добавок в лечении заболеваний скелета. Представлены возможности успешной терапии постменопаузального остеопороза без использования таких средств на примере препарата Остео-Вит D3, не содержащего в своем составе кальций и высокие дозы кальциферола, но повышающего минеральную плотность костной ткани и уменьшающего объемы кальцификатов в сосудах и почках.

Ключевые слова: 
остеопороз
остеопения
перелом
кальций
кальцийсодержащие препараты
кальцификация сосудов
нефролитиаз
камни в почках
Остео-Вит D3
витамин D.

Для цитирования
Струков В.И., Сергеева-Кондраченко М.Ю., Денисова А.Г. и др. Кальцификация сосудов и почек как следствие приема высокодозированных препаратов кальция и витамина D . Врач, 2024; (2): 79-88 https://doi.org/10.29296/25877305-2024-02-15


Список литературы: 
  1. Пигарова Е.А. Физиология обмена кальция в почках. Ожирение и метаболизм. 2011; 8 (4): 3–8 [Pigarova E.A. Physiology of calcium metabolism in kidneys. Obesity and metabolism. 2011; 8 (4): 3–8 (in Russ.)]. DOI: org/10.14341/2071-8713-5296
  2. Bading H. Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci. 2013; 14 (9): 593. DOI: 10.1038/nrn3531
  3. Orrenius S., Gogvadze V., Zhivotovsky B. Calcium and mitochondria in the regulation of cell death. Biochem Biophys Res Commun. 2015; 460: 72–81. DOI: 10.1016/j.bbrc.2015.01.137
  4. Пигарова Е.А. Роль кальция в профилактике и лечении остеопороза. Эффективная фармакотерапия. Эндокринология. 2015; 46: 20–5 [Pigarova E.A. The Role of Calcium in Preventing and Treating Osteoporosis. Effective Pharmacotherapy. Endocrinology. 2015; 46: 20–5 (in Russ.)].
  5. Батурин А.К. Состояние питания и пути его оптимизации. Федеральные и региональные аспекты. Здоровое питание – здоровая нация: мат-лы Всерос. научно-практич. конференции. Москва, 16–19 сентябрь, 2009 [Baturin A.K. Sostoyanie pitaniya i puti ego optimizatsii. Federal'nye i regional'nye aspekty. Zdorovoe pitanie – zdorovaya natsiya: mat-ly Vseros. nauchno-praktich. konferentsii. Moskva, 16–19 sentyabr', 2009 (in Russ.)].
  6. Никитинская О.А., Торопцова Н.В. «Остеоскрининг Россия»: потребление кальция жителями различных регионов страны. Современная медицина. Травматология/Ортопедия. Хирургия. 2018; 2 (10): 43–6 [Nikitinskaya O.A., Toroptsova N.V. "Osteoscreening Russia": calcium consumption by residents of different regions of the country. Modern Medicine. Traumatology/Orthopedics. Surgery. 2018; 2 (10): 43-6 (in Russ.)].
  7. Anderson J.J.B., Roggenkamp K.J., Suchindran C.M. Calcium intakes and femoral and lumbar bone density of elderly US men and women: National Health and Examination Survey 2005–2006 analysis. J Clin Endocrinol Metab. 2012; 97: 4531–9. DOI: 10.1210/jc.2012-1407
  8. Tai V., Leung W., Grey A. et al. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015; 351: h4183. DOI: 10.1136/bmj.h4183
  9. Bolland M.J., Barber P.A., Doughty R.N. et al. Vascular events in healthy older women receiving calcium supplementation: Randomized controlled trial. BMJ. 2008; 336 (7638): 262–6. DOI: 10.1136/bmj.39440.525752.BE
  10. Bolland M.J., Avenall A., Baron J.A. et al. Effect of calcium supplementation on risk of myocardial infarction and cardiovascular events: Meta-analysis. BMJ. 2010; 341: C3691. DOI: 10.1136/bmj.c3691
  11. Pennti K., Tupperainen M.T., Honkanen R. et al. Use of calcium supplements and the risk of coronary heart disease in 52–62-year-old women: The kuopio osteoporosis risk factor and prevention study. Maturitas. 2009; 63 (1): 73–8. DOI: 10.1016/j.maturitas.2009.03.006
  12. Reid I.R., Bolland N.J., Avenell A. et al. Cardiovascular effects of calcium supplementation. Osteoporos Int. 2011; 22 (6): 1649–58. DOI: 10.1007/s00198-011-1599-9
  13. Bauer D.C. Clinical practice. Calcium supplements and fracture prevention. N Engl J Med. 2013; 369 (16): 1537–43. DOI: 10.1056/NEJMcp1210380
  14. Anderson J.J.B., Klemmer P. J. Risk of High Dietary Calcium for Arterial Calcification in Older Adults. Nutrients. 2013; 5 (10): 3964–74. DOI: 10.3390/nu5103964
  15. Karp H.J., Ketola M.E., Lamberg-Allardt C.J.E. Acute effects of calcium carbonate, calcium citrate and potassium citrate on markers of calcium and bone metabolism in young women. Br J Nutr. 2009; 102: 1341–7. DOI: 10.1017/S0007114509990195
  16. Heaney R.P., Dowell M.S., Bierman J., et al. Absorbability and cost effectiveness in calcium supplementation. J Am Coll Nutr. 2001; 20: 239–46. DOI: 10.1080/07315724.2001.10719038
  17. Wang T.K., Bolland M.J., van Pelt N.C. et al. Relationships between vascular calcification, calcium metabolism, bone density, and fractures. J Bone Miner Res. 2010; 25 (12): 2777–85. DOI: 10.1002/jbmr.183
  18. Chandran M., Tay D., Mithal A. Supplemental calcium intake in the aging individual: implications on skeletal and cardiovascular health. Aging Clin Exp Res. 2019; 31 (6): 765–81. DOI: 10.1007/s40520-019-01150-5
  19. Spiegel D.M., Brady K. Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets. Kidney Int. 2011; 81: 1116–22. DOI: 10.1038/ki.2011.490
  20. Balesaria S., Sangha S., Walters J.R. Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol. 2009; 297 (6): G1193-7. DOI: 10.1152/ajpgi.00237.2009
  21. Talmage R.V. Foreword. In Calcium and Phosphorus in Health and Disease; Anderson J.J.B., Garner S.C., Eds.; CRC Press: Boca Raton, FL, USA, 1996.
  22. Watson K.E., Bostrom K., Ravindranath R. et al. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 1994; 93 (5): 2106–13. DOI: 10.1172/JCI117205
  23. Demer L.L. Vascular calcification and osteoporosis: Inflammatory responses to oxidized lipids. Int J Epidemiol. 2002; 31 (4): 737–41. DOI: 10.1093/ije/31.4.737
  24. Giachelli C.M. The emerging role of phosphate in vascular calcification. Kidney Int. 2009; 75: 890–8. DOI: 10.1038/ki.2008.644
  25. Rensen S.S.M., Doevendans P.A.F.M., van Eys G.J.J.M. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J. 2007; 15: 100–8. DOI: 10.1007/BF03085963
  26. Iyemere V.P., Proudfoot D., Weissberg P.L. et al. Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification. J Intern Med. 2006; 260: 192–210. DOI: 10.1111/j.1365-2796.2006.01692.x
  27. Alves R.D.A.M., Eijken M., van de Peppel J. et al. Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries. BMC Genomics. 2014; 15: 965. DOI: 10.1186/1471-2164-15-965
  28. Houben E., Neradova A., Schurgers L.J. et al. The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review. G Ital Nefrol. 2016; 33: 6.
  29. Reynolds J.L., Joannides A.J., Skepper J.N. et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol. 2004; 15: 2857–67. DOI: 10.1097/01.ASN.0000141960.01035.28
  30. Kapustin A.N., Chatrou M.L., Drozdov I. et al. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circ Res. 2015; 116: 1312–23. DOI: 10.1161/CIRCRESAHA.116.305012
  31. Huybers S., Bindels R.J. Vascular calcification in chronic kidney disease: new developments in drug therapy. Kidney Int. 2007; 72: 663–5. DOI: 10.1038/sj.ki.5002477
  32. Tukaj C., Kubasik-Juraniec J., Kraszpulski M. Morphological changes ofaortal smooth muscle cells exposed to calcitriol in culture. Med Sci Monit. 2000; 6: 668–74.
  33. Rebsamen M.C., Sun J., Norman A.W. et al. 1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation ofphosphatidylinositol 3-kinase. Circ Res. 2002; 91: 17–24. DOI: 10.1161/01.res.0000025269.60668.0f
  34. Tukaj C. Enhanced proliferation of aortal smooth muscle cells treated by 1,25(OH)2D3 in vitro coincides with impaired formation of elastic fibres. Int J Exp Pathol. 2008; 89: 117–24. DOI: 10.1111/j.1365-2613.2008.00578.x
  35. Inoue T., Kawashima H. 1,25-Dihydroxyvitamin D3 stimulates 45Ca2+-uptake by cultured vascular smooth muscle cells derived from rat aorta. Biochem Biophys Res Commun. 1988; 152 (3): 1388–94. DOI: 10.1016/s0006-291x(88)80439-x
  36. Nordin B.E.C. Calcium, Phosphate, and Magnesium Metabolism. Churchill Livingstone: Edinburgh, UK, 1976, p. 41.
  37. Roberts W.C. The senile cardiac calcification syndrome. Am J Cardiol. 1986; 58 (6): 572–4. DOI: 10.1016/0002-9149(86)90045-7
  38. Doherty T.M., Fitzpatrick L.A., Inoue D. et al. Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev. 2004; 25: 629–72. DOI: 10.1210/er.2003-0015
  39. Kantor E.D., Rehm C.D., Du M. et al. Trends in dietary supplement use among US adults from 1999–2012. JAMA. 2016; 316: 1464–74. DOI: 10.1001/jama.2016.14403
  40. Anderson J.J.B., Kruszka B., Delaney J.A.C. et al. Calcium Intake From Diet and Supplements and the Risk of Coronary Artery Calcification and its Progression Among Older Adults: 10-Year Follow-up of the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Heart Assoc. 2016; 5 (10): e003815. DOI: 10.1161/JAHA.116.003815
  41. Bazarbashi N., Kapadia S.R., Nicholls S.J. et al. Oral Calcium Supplements Associate With Serial Coronary Calcification: Insights From Intravascular Ultrasound. JACC Cardiovasc Imaging. 2021; 14 (1): 259–68. DOI: 10.1016/j.jcmg.2020.06.030
  42. Bouderlique E., Tang E., Zaworski J. et al. Vitamin D and Calcium Supplementation Accelerate Vascular Calcification in a Model of Pseudoxanthoma Elasticum. Int J Mol Sci. 2022; 23 (4): 2302. DOI: 10.3390/ijms23042302
  43. Kassis N., Hariri E.H., Karrthik A.K. et al. Supplemental calcium and vitamin D and long-term mortality in aortic stenosis FREE. Heart. 2022; 108: 964–72. DOI: 10.1136/heartjnl-2021-320215
  44. Rennenberg R.J., Kessels A.G.H., Schurgers L.J. et al. Vascular calcification as a marker of increased cardiovascular risk: a meta-analysis. Vasc Health Risk Manag. 2009; 5: 185–97. DOI: 10.2147/vhrm.s4822
  45. Detrano R., Guerci A.D., Carr J.J. et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008; 358: 1336–45. DOI: 10.1056/NEJMoa072100
  46. Vliegenthart R., Hollander M., Breteler M.M.B. et al. Stroke is associated with coronary calcification as detected by electron-beam CT: the Rotterdam Coronary Calcification Study. Stroke. 2002; 33: 462–5. DOI: 10.1161/hs0202.103071
  47. Heaney R.P., Kopecky S., Maki K.C., et al. A review of calcium supplements and cardiovascular disease risk. Adv Nutr. 2012; 3: 763–71. DOI: 10.3945/an.112.002899
  48. Li K., Kaaks R., Linseisen J. et al. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart. 2012; 98: 920–5. DOI: 10.1136/heartjnl-2011-301345
  49. Bolland M.J., Grey A., Avenell A. et al. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ. 2011; 342: d2040. DOI: 10.1136/bmj.d2040
  50. Khan S.U., Khan M.U., Riaz H. et al. Effects of nutritional supplements and dietary interventions on cardiovascular outcomes: an umbrella review and evidence MAP. Ann Intern Med. 2019; 171: 190–8. DOI: 10.7326/M19-0341
  51. Bolland M.J., Grey A., Reid I.R. Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf. 2013; 4: 199–210. DOI: 10.1177/2042098613499790
  52. Larsson S.C. Are calcium supplements harmful to cardiovascular disease? JAMA Intern. Med. 2013; 173: 647–8. DOI: 10.1001/jamainternmed.2013.3769
  53. Reid I.R. Cardiovascular effects of calcium supplements. Nutrients. 2013; 5: 2522–9. DOI: 10.3390/nu5072522
  54. Xiao D.Q., Murphy R. Dietary and supplemental calcium intakes in relation to mortality from cardiovascular diseases in the NIH-AARP Diet and Health Study. JAMA Intern. 2013; 173: 639–46. DOI: 10.1001/jamainternmed.2013.3283
  55. Tankeu A.T., Ndip Agbor V., Noubiap J.J. Calcium supplementation and cardiovascular risk: a rising concern. J Clin Hypertens. 2017; 19: 640–6. DOI: 10.1111/jch.13010
  56. Niederhoffer N., Bobryshev Y., Lartaud-Idjouadiene I. et al. Aortic calcification produced byvitamin D3 plus nicotine. J Vasc Res. 1997; 34: 386e98. DOI: 10.1159/000159247
  57. Gong C., Li L., Qin C. et al. The involvement of Notch1-RBP-Jk/Msx2 signaling pathway in aortic calcification of diabetic nephropathy rats. J Diabetes Res. 2017; 2017: 8968523. DOI: 10.1155/2017/8968523
  58. Bas A., Lopez I., Perez J. et al. Reversibility of calcitriol-induced medialartery calcification in rats with intact renal function. J Bone Miner Res. 2006; 21: 484–90. DOI: 10.1359/JBMR.051211
  59. Henley C., Colloton M., Cattley R.C. et al. 1,25-Dihydroxyvitamin D3 but notcinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcificationin a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant. 2005; 20: 1370–7. DOI: 10.1093/ndt/gfh834
  60. Tang F.T., Chen S.R., Wu X.Q. et al. Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress. Calcif Tissue Int. 2006; 79 (5): 326–39. DOI: 10.1007/s00223-006-0004-8
  61. Goldsmith D.J., Covic A., Sambrook P.A. et al. Vascular calcification in long-term haemodialysis patients in a single unit: a retrospective analysis. Nephron. 1997; 77: 37–43. DOI: 10.1159/000190244
  62. Briese S., Wiesner S., Will J.C. et al. Arterial and cardiac disease inyoung adults with childhood-onset end-stage renal disease-impact ofcalcium and vitamin D therapy. Nephrol Dial Transplant. 2006; 21: 1906–14. DOI: 10.1093/ndt/gfl098
  63. Thamattoor A. Race/ethnicity differences in vitamin D levels and impact on cardiovascular disease, bone health, and oral health. medRxiv. 2021. DOI: 10.1101/2021.01.02.21249149 URL: https://www.medrxiv.org/content/10.1101/2021.01.02.21249149v1
  64. Hsu J.J., Tintut Y., Demer L.L. Vitamin D and Osteogenic Differentiation in the Artery Wall. Clin J Am Soc Nephrol. 2008; 3 (5): 1542–47. DOI: 10.2215/CJN.01220308
  65. Shroff R., Egerton M., Bridel M. et al. A bimodal association of vitamin Dlevels and vascular disease in children on dialysis. J Am Soc Nephrol. 2008; 19: 1239–46. DOI: 10.1681/ASN.2007090993
  66. Bargagli M., Moochhala S., Robertson W.G., et al. Urinary Metabolic Profile and Stone Composition in Kidney Stone Formers with and without Heart Disease. J Nephrol. 2022; 35 (3): 851–7. DOI: 10.1007/s40620-021-01096-w
  67. Ferraro P.M., Marano R., Primiano A., et al. Stone Composition and Vascular Calcifications in Patients with Nephrolithiasis. J Nephrol. 2019; 32 (4): 589–94. DOI: 10.1007/s40620-019-00619-w
  68. Liu C.-J., Cheng C.-W., Tsai Y.-S. et al. Crosstalk between Renal and Vascular Calcium Signaling: The Link between Nephrolithiasis and Vascular Calcification. Int J Mol Sci. 2021; 22 (7): 3590. DOI: 10.3390/ijms22073590
  69. Villa-Bellosta R. Vascular calcification: key roles ofphosphate and pyrophosphate. Int J Mol Sci. 2021; 22 (24): 13536. DOI: 10.3390/ijms222413536
  70. Lieske J.C., Rule A.D., Krambeck A.E. et al. Stone composition as a function of age and sex. Clin J Am Soc Nephrol. 2014; 9 (12): 2141–6. DOI: 10.2215/CJN.05660614
  71. Khan S.R., Canales B.K., Dominguez-Gutierrez P.R. Randall’s plaque and calcium oxalate stone formation:role for immunity and inflammation. Nat Rev Nephrol. 2021; 17 (6): 417–33. DOI: 10.1038/s41581-020-00392-1
  72. Khan S.R. Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis. Transl Androl Urol. 2014; 3: 256–76. DOI: 10.3978/j.issn.2223-4683.2014.06.04
  73. Huang L., Hu J., Xue C. et al. Vascular calcification on the risk of kidney stone: a meta-analysis. Ren Fail. 2023; 45 (1): 2183727. DOI: 10.1080/0886022X.2023.2183727
  74. Grieff M., Bushinsky D.A. Nutritional prevention and treatment of kidney stones. In: Kalantar-Zadeh K. (ed) Kopple J.D., Massry S.G. Academic Press, Nutritional management of renal disease, 2013, pp. 699–709.
  75. Worcester E.M., Coe F.L. Clinical practice Calcium kidney stones. N Engl J Med. 2010; 363 (10): 954–63. DOI: 10.1056/NEJMcp1001011
  76. Pak C.Y.C., Sakhaee K., Moe O.W. et al. Defining Hypercalciuria in Nephrolithiasis. Kidney Int. 2011; 80: 777–82. DOI: 10.1038/ki.2011.227
  77. Wallace R.B., Wactawski-Wende J., O’Sullivan M.J. et al. Urinary Tract Stone Occurrence in the Women’s Health Initiative (WHI) Randomized Clinical Trial of Calcium and Vitamin D Supplements. Am J Clin Nutr. 2011; 94: 270–7. DOI: 10.3945/ajcn.110.003350
  78. Curhan G.C., Willett W.C., Speizer F.E. et al. Comparison of Dietary Calcium with Supplemental Calcium and Other Nutrients as Factors Affecting the Risk for Kidney Stones in Women. Ann Intern Med. 1997; 126: 497–504. DOI: 10.7326/0003-4819-126-7-199704010-00001
  79. Curhan G.C., Willett W.C., Rimm E.B. et al. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993; 328 (12): 833–8. DOI: 10.1056/NEJM199303253281203
  80. Kozyrakis D., Paridis D., Karatzas A. et al. Do Calcium Supplements Predispose to Urolithiasis? Curr Urol Rep. 2017; 18 (3): 17. DOI: 10.1007/s11934-017-0668-9
  81. Jackson R.D., LaCroix A.Z., Gass M. et al. Women’s Health Initiative Investigators Calcium plus vitamin Dsupplementation and the risk of fractures. N Engl J Med. 2006; 354: 669–83. DOI: 10.1056/NEJMoa055218
  82. Lappe J., Watson P., Travers-Gustafson D. et al. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017; 317: 1234–43. DOI: 10.1001/jama.2017.2115
  83. Avenell A., Mak J.C., O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014; 4: CD000227. DOI: 10.1002/14651858.CD000227.pub4
  84. Bjelakovic G., Gluud L.L., Nikolova D. et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. 2014; 1: CD007470. DOI: 10.1002/14651858.CD007470.pub3
  85. Wang H., Man L., Li G., Huang G., Liu N. Association between serum vitamin D levels and the risk ofkidney stone: Evidence from a meta-analysis. Nutr J. 2016; 15: 32. DOI: 10.1186/s12937-016-0148-y
  86. Hu H., Zhang J., Lu Y. et al. Associationbetween Circulating Vitamin D Level and Urolithiasis: A Systematic Review and Meta-Analysis. Nutrients. 2017; 9: 301. DOI: 10.3390/nu9030301
  87. U.S. Preventive Services Task Force. Vitamin D and Calcium Supplementation to Prevent Cancer and Osteoporotic Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement (DRAFT). URL: http://www.uspreventiveservicestaskforce.org/uspstf12/vitamind/draftrecvitd.htm
  88. Bischoff-Ferrari H.A., Dawson-Hughes B., Baron J.A. et al. Calcium intake and hip fracture risk in men and women: A meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr. 2007; 86: 1780–90. DOI: 10.1093/ajcn/86.5.1780
  89. Zhao J.-G., Zeng X.-T., Wang J. et al. Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults a systematic review and meta-analysis. JAMA. 2017; 318: 2466–82. DOI: 10.1001/jama.2017.19344
  90. Chiodini I., Bolland M.J. Calcium supplementation in osteoporosis: useful or harmful? Eur Soc Endocri. 2018; 178: D13–25. DOI: 10.1530/EJE-18-0113
  91. Bolland M.J., Leung W., Tai V. et al. Calcium intake and risk of fracture: systematic review. BMJ. 2015; 351: h4580. DOI: 10.1136/bmj.h4580
  92. Newman A.B., Naydeck B.L., Whittle J. et al. Racial differences in coronary artery calcification in older adults. Arterioscler Thromb Vasc Biol. 2002; 22 (3): 424–30. DOI: 10.1161/hq0302.105357
  93. Freedman B.I., Register T.C. Effect of race and genetics on vitamin D metabolism, bone and vascular health. Nat Rev Nephrol. 2012; 8: 459–66. DOI: 10.1038/nrneph.2012.112
  94. Трифонов В.Н., Елистратова Ю.А., Елистратов К.Г. и др. Способ приготовления расплода трутневого адсорбированного и его состав. Патент на изобретение RU 2491078C2, 27.08.2013. Заявка №2011137992/15 от 16.09.2011 [Trifonov V.N., Elistratova Yu.A., Elistratov K.G. et al. Sposob prigotovleniya rasploda trutnevogo adsorbirovannogo i ego sostav. Patent na izobretenie RU 2491078C2, 27.08.2013. Zayavka №2011137992/15 ot 16.09.2011 (in Russ.)].
  95. Бурмистрова Л.А. Физико-химический анализ и биохимическая оценка биологической активности трутневого расплода. Дисс. ... канд. биол. наук. Рязань, 1999 [Burmistrova L.A. Fiziko-khimicheskii analiz i biokhimicheskaya otsenka biologicheskoi aktivnosti trutnevogo rasploda. Diss. ... kand. biol. nauk. Ryazan, 1999 (in Russ.)].
  96. Василенко Ю.К., Климова О.В., Лазарян Д.С. Биологические свойства трутневого расплода в условиях длительной гиперлипидемии. Химико-фармацевтический журнал. 2002; 36 (8): 34–6 [Vasilenko Y.K., Klimova O.V., Lazaryan D.S. Biological properties of trout brood under conditions of prolonged hyperlipidemia. Chemico-Pharmaceutical Journal. 2002; 36 (8): 34–6 (in Russ.)].
  97. Крылов В.Н., Агафонов А.В., Кривцов Н.И. и др. Теория и средства апитерапии. М.: ГНУ НИИП Россельхозакадемия, 2007 [Krylov V.N., Agafonov A.V., Krivtsov N.I. et al. Teoriya i sredstva apiterapii. M.: GNU NIIP Rossel'khozakademiya, 2007 (in Russ.)].
  98. Corotchi M.C., Popa M.A., Simionescu M. Testosterone stimulates proliferation and preserves stemness of human adult mesenchymal stem cells and endothelial progenitor cells. Rom J Morphol Embryol. 2016; 57 (1): 75–80.
  99. Wacker M., Holick M.F. Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013; 5 (1): 111–48. DOI: 10.3390/nu5010111
  100. Bikle D.D. Vitamin D and bone. Curr Osteoporos Rep. 2012; 10 (2): 151–9. DOI: 10.1007/s11914-012-0098-z
  101. Suda T., Takahashi N., Abe E. Role of vitamin D in bone resorption. J Cell Biochem. 1992; 49 (1): 53–8. DOI: 10.1002/jcb.240490110
  102. Майлян Э.А., Резниченко Н.А., Майлян Д.Э. Регуляция витамином D метаболизма костной ткани. Медицинский вестник Юга России. 2017; 1: 12–20 [Maylyan E.A., Rheznichenko N.A., Maylyan D.E. Vitamin D regulation of bone metabolism. Medical Herald of the South of Russia. 2017; 1: 12–20 (in Russ.)]. DOI: 10.21886/2219-8075-2017-1-12-20
  103. Biswas P., Zanello L. P. 1alpha,25(OH)(2) vitamin D(3) induction of ATP secretion in osteoblasts. J Bone Miner Res. 2009; 24 (8): 1450–60. DOI: 10.1359/jbmr.090306
  104. Lehmann U., Hirche F., Stangl G.I. et al. Bioavailability of vitamin D(2) and D(3) in healthy volunteers, a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2013; 98 (11): 4339–43. DOI: 10.1210/jc.2012-4287
  105. Спиричев В.Б. Витамины и минеральные вещества в комплексной профилактике и лечении остеопороза. Вопросы питания. 2003; 1: 34–43 [Spirichev V.B. Vitamins and minerals in the complex prevention and treatment of osteoporosis. Voprosy Pitaniya. 2003; 1: 34–43 (in Russ.)].
  106. Юрова О., Марченкова Л. Опыт применения БАД Остеомед Форте в комплексной программе реабилитации пациентов с переломом дистального отдела предплечья на фоне системного остеопороза. Врач. 2020; 31 (2): 47–52 [Yurova O., Marchenkova L. The experience of using of comprehensive rehabilitation program with dietary supplements Osteomed Forte in patients with a osteoporotic distal forearm fracture. Vrach. 2020; 31 (2): 47–52 (in Russ.)]. DOI: 10.29296/25877305-2020-02-11
  107. Струков В.И., Виноградова О.П., Сергеева-Кондраченко М.Ю. и др. Иммунотерапия постменопаузального остеопороза и других заболеваний костно-суставной системы на фоне гормональной недостаточности. Акушерство и гинекология. Новости. Мнения. Обучение. 2022; 10 (2): 47–55 [Strukov V.I., Vinogradova O.P., Sergeeva-Kondrachenko M.Yu. et al. Immunotherapy of postmenopausal osteoporosis and other osteoarticular diseases against the background of hormonal deficiency. Obstetrics and Gynecology: News, Opinions, Training. 2022; 10 (1): 47–55 (in Russ.)]. DOI: 10.33029/2303-9698-2022-10-2-47-55
  108. Виноградова О.П., Сергеева-Кондраченко М.Ю., Панина Е.С. и др. Иммунотерапия остеоартроза на фоне остеопороза. Терапевт. 2023; 1: 6–15 [Vinogradova O.P., Sergeeva-Kondrachenko M.Yu., Panina E.S. et al. Immunotherapy of osteoarthritis against the background of osteoporosis. Therapist. 2023; 1: 6–15 (in Russ.)]. DOI: 10.33920/MED-12-2301-01
  109. Струков В.И., Алексеева Н.Ю., Петрова Е.В. и др. Остеобиотик «Остео-Вит D3» как средство лечения и профилактики болезней опорно-двигательного аппарата медикаментозного генеза. Пятиминутка. 2020; 2 (57): 28–33 [Strukov V.I., AlekseevaN.Yu., Petrova E.V. et al. Osteobiotic "Osteo-Vit D3" as a means of treatment and prevention of diseases of the musculoskeletal system of medicinal genesis. Pyatiminutka. 2020; 2 (57): 28–33 (in Russ.)].